Activation of p38 MAPK pathway contributes to the.
Research Paper highly conserved among all organisms including. The p38 MAPK signaling pathway has been involved in a number of important biological activities, such as proliferation, inflammation, cell death, and aging (18). The activation of p38 is dependent not only on stimuli but also on cell types. In reproductive cells, it plays a pivotal role in oocyte maturation (19-22) and.
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A dissection of molecular pathways between VEGF-induced angiogenesis and vascular permeability would be desirable for the development of angiogenic and anti-angiogenic therapies. Therefore, our specific objective was to investigate the role of the p38 MAPK as the signaling molecule that separates these two processes.
ABSTRACTThe family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biological processes. In this review, we highlight the known characteristics and components of the.
Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway. Hongtao He. Department of Hepatobiliary Surgery, Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province, Shijiazhuang, China. These authors contributed equally to this work.Search for more papers by this author. Kuangyuan Qiao. Basic Medical College of Hebei Medical.
Our data showed that TMZ treatment induces the activation of Nrf2 and p38 MAPK signaling in glioma cells, while p38 inhibition abolished the effect of TMZ on Nrf2. Further study revealed that Nrf2 silencing was able to enhance the response of glioma cells to TMZ. Additionally, Nrf2 overexpression overrides the effect of p38 MAPK activation on Temozolomide resistance. In conclusions, we.
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